Evaluation of Polyethylene Oxide Compacts as Gastroretentive Delivery Systems

Bimodal Gastroretentive Drug Delivery Systems of Lamotrigine: Formulation and Evaluation

Gastroretentive bimodal drug delivery systems of lamotrigine were developed using immediate release and extended release segments incorporated in a hydroxypropyl methylcellulose capsule and in vitro and in vivo evaluations were conducted. In vivo radiographic studies were carried out for the optimized formulation in healthy human volunteers with replacement of drug polymer complex by barium sul...

Gastroretentive drug delivery systems: a review

The purpose of writing this review on gastroretentive drug delivery systems was to compile the recent literature with special focus on various gastroretentive approaches that have recently become leading methodologies in the field of site-specific orally administered controlled release drug delivery. In order to understand various physiological difficulties to achieve gastric retention, we have...

Gastroretentive Drug Delivery Systems: a Promising Approach

Formulation and Evaluation of Gastroretentive Drug Delivery System of Acyclovir as Mucoadhesive Nanoparticles

The objective of this study was formulation and evaluation of mucoadhesive nanoparticles of acyclovir. Nanoparticles were prepared by one step desolvation method by using gelatin as a mucoadhesive polymer. The effects of amount of gelatin and Pluronic F-68 on particle size, polydispersity index, entrapment efficiency, loading efficiency, mucoadhesive strength were studied. Nanoparticulate formu...

Floating Drug Delivery of Nevirapine as a Gastroretentive System

A multiple-unit floating drug delivery system based on gas formation technique was developed, in order to prolong the gastric residence time and to increase the overall bioavailability of the dosage form. The floating bead formulations were prepared by dispersing nevirapine together with calcium carbonate in a mixture of sodium alginate and hydroxypropyl methylcellulose solution and then drippi...